Medzus Laboratories has a dedicated unit focused on providing support and testing for combination products in compliance with related regulatory standards.
The FDA & ISO Guidance document - "Technical Considerations for Pen, Jet, and Related Injectors Intended for Use with Drugs and Biological Products" recommends that the final injector for submission undergoes a variety of performance tests.
Luer Lock Adaptor Collar and Tip Cap Pull-off Force and Torques
Luer Cone Breakage Resistance
Luer Connectivity
Tip Cap Closure System Forces and Torques
Needle Penetration and Pull-out Forces
Burst Resistance
Flange Breakage Resistance
Break Loose, Extrusion and Lubrication
Deliverable and Residual Volume
Liquid Leakage Beyond Plunger and Fluid Pressure
Performance Related Shelf Life and Storage
Technical Investigations and Failure Root Cause Analysis
Residual Seal Force
Spike Penetrability
Fragmentation
Spike Retention and Sealing Capacity
Extractables and Leachables
Particle Analysis
Container Closure Integrity
CCIT Integrity Test
ISO 11608 -1: Needle-based injection systems Testing
ISO 11608 -3: Finished containers Testing
ISO 11608 -5: Automated Function Testing
ISO 11608 -2: Needles Testing
ISO 11608 -4: Pen Injectors Testing
ISO 11608 -6: On Body Delivery System Testing